A client of mine is looking to convert a critical 'application' based on multiple (very complex) spreadsheets into a web app. As part of this they'd like some of the web pages they use to enter/model data to resemble a spreadsheet as much as possible.
The coding languages to be used and platform is still open to debate, so ASP.NET against IE or PHP/Flex against Firefox, or some other combination is fine - this will be driven by the business requirement not the platform.
I'd say this comes down to data grids.
It really comes down to what platform mix you want to use.
Also, why do you want to bind an asp.net page to IE instead of Firefox?
Check out ZK Spreadsheet its cool.
It sounds like EASA might meet your needs. It's a codeless app development tool in use at companies like Zurich, GE, HP. You may like to have a look at http://www.easasoftware.com/spreadsheets. Hope this helps.
Check out SpreadsheetGear, as is a .Net component that will allow you to read / write Excel files and execute macros. You can preserve the logic of the spreadsheets and use them to power you web site.
For a front end you may want to check out Telerik as people have created a spreadsheet like interface with the Telerik grid control.
I would consider a solution based on google docs/apps or similar and background web services.
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